You prepare a newsletter, send it to your list and see little response. That does not tell you whether the problem was delivery, the audience, the offer or incomplete measurement. Start by separating those questions.
The checks below cover the common technical and organisational causes: domain authentication, sending services, complaints, bounces, unsubscribe options, sender identity and sending rhythm. Record the evidence for each mailing instead of treating a low open rate as proof that everything went to spam.